Signaling to the ribosome in cancer - It is more than just mTORC1

KM Hannan; E Sanij; N Hein; RD Hannan; RB Pearson

Journal article

Signaling to the ribosome in cancer - It is more than just mTORC1

KM Hannan, E Sanij, N Hein, RD Hannan, RB Pearson

IUBMB Life | Published : 2011

DOI: 10.1002/iub.428

Abstract

It is becoming increasingly clear that dysregulation of protein synthesis contributes to a range of diseases characterized by tissue overgrowth. These include arterial stenosis, cardiac hypertrophy, hamartomas, and cancer. The central hub for the regulation of protein synthesis is the ribosome, where the key signaling pathways downstream of RAS, MYC, and phosphatidylinositol-3-kinase (PI3K) converge to confer exquisite, coordinated control of ribosome synthesis and function. Such cooperation ensures strict regulation of protein synthesis rates and cell growth. This review will focus on the role the PI3K/AKT/mammalian target of rapamycin complex 1 (mTORC1) pathway plays in regulating ribosome..

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University of Melbourne Researchers

Elaine Sanij Author

Richard Pearson Author

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Funding Acknowledgements

This work was supported by grants from the National Health and Medical Research Council (NHMRC) of Australia to R.D.H (NHMRC #166908 & #251688) and to R.B.P. (NHMRC #509087 & #400116) and from Cancer Council Victoria to R.B.P. This article was initially published in the member magazine of the Australian Society for Biochemistry and Molecular Biology, The Australian Biochemist.